Gut microbiota: a newly identified environmental factor in systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that predominantly affects women of childbearing age and characterized by the damage to multiple target organs. The pathogenesis SLE complex, its etiology mainly involves genetic environmental factors. At present, there still lack effective means cure SLE. In recent years, growing evidence has shown gut microbiota, as an factor, triggers autoimmunity through potential mechanisms including translocation molecular mimicry, leads immune dysregulation, contributes development Dietary intervention, drug therapy, probiotics supplement, fecal microbiome transplantation other ways modulate microbiota appear be treatment for this review, dysbiosis in SLE, linking dysregulation associated with are summarized.